Pro-lymphocytic Leukemia

What is Pro-lymphocytic Leukemia?

Pro-lymphocytic leukemia is a variant of chronic lymphocytic leukemia with larger and less differentiated cells.

Pathogenesis during Pro-lymphocytic Leukemia

The following variants of prolymphocytic leukemia are distinguished:

  • The B-cell variant is the most common.
  • T-cell variant – is rare; Helper subpopulations are detected more often than suppressor subpopulations.

Diagnosis of Prolymphocytic Leukemia

With prolymphocytic leukemia in the peripheral blood and bone marrow punctate prolymphocytes prevail (more than 55%). Pathological cells in 75-80% of patients have a B-cell phenotype, which in their biological characteristics are more mature lymphoid elements than lymphocytes in a typical B-cell chronic lymphocytic leukemia. In 20-25% of patients, the cells have a T-cell phenotype, in such cases the disease is more severe, with severe leukocytosis, progresses rapidly, therapy is not very effective.

A characteristic feature of prolymphocytic leukemia is expressed leukocytosis and splenomegaly with slightly enlarged lymph nodes, as well as resistance to cytostatics.

Treatment of Pro-lymphocytic Leukemia

Pro-lymphocytic leukemia is usually resistant to polychemotherapy.