Plasma Cell Acute Leukemia

What is Plasma Cell Acute Leukemia?

Plasma cell acute leukemia, according to the literature, is a rare variant of leukemia.

This disease, like B-cell acute leukemia, according to modern concepts of hematopoiesis should belong to the lymphoid form.

Symptoms of Plasma Cell Acute Leukemia

In most patients with plasma cell leukemia, the tumor process is widespread – the diseased vessels, respiratory system, gastrointestinal tract, kidneys, and skin are affected. Often leukemids are detected on the skin, severe hemorrhagic syndrome.

Diagnosis of Plasma Cell Acute Leukemia

Wide-plasma plasma leukemic cells, with the nucleus of the correct form and basophilic cytoplasm without inclusions. The core is often eccentric.

Leukemic plasma cells give a negative reaction to myeloperoxidase, with Sudan black B, are positive in reaction to acid phosphatase. In the cytoplasm of 30-80% of leukemia cells, either coarse-grained SIC-positive granules filling the entire cytoplasm are found, or many small granules against a background of diffuse staining. In general, the CHIC reaction is always intense.

The activity of a-naphthyl acetate esterase is high in 20-100% of cells and is almost not inhibited by NaF at a concentration of 1.5 mg / ml. The average activity of LDH, LDH, a-GFDM in leukemic plasma cells is 25-30 granules per cell.

The affiliation of these leukemic cells with the plasma series is possible by immunofluorescence reaction. On fixed smears of punctured bone marrow of patients, intracellular immunoglobulins, most often immunoglobulin G., are found in the cytoplasm of leukemic cells.

Treatment of Plasma Cell Acute Leukemia

Despite the active anti-leukemia treatment using polychemotherapy, in children suffering from acute plasma leukemia, it is not possible to get remission.

The forecast is unfavorable.